2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one
CAS: 521937-07-5
Molecular Formula: C12H11NO3
2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one - Names and Identifiers
2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one - Physico-chemical Properties
| Molecular Formula | C12H11NO3 |
| Molar Mass | 217.22 |
| Density | 1.341±0.06 g/cm3(Predicted) |
| Melting Point | 244-247 °C(Solv: isopropanol (67-63-0); isopropanol (67-63-0)) |
| Boling Point | 531.8±38.0 °C(Predicted) |
| Solubility | DMSO: ≥15mg/mL |
| Appearance | powder |
| Color | white to tan |
| pKa | 9.00±0.20(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | In LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocked PMA-induced HDAC5 nuclear export and blocked PKD-mediated protein transport. In prostate cancer cells, CID755673 effectively blocks cell migration and invasion and exhibits inhibitory activity on tumor cell proliferation and cell cycle distribution. In addition, CID755673 alters primary human NK cell effector function. |
| In vivo study | In a rat model of acute pancreatitis, CID755673, by inhibiting PKD/ PKD1, significantly improved the severity of necrosis and pancreatitis. |
2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.604 ml | 23.018 ml | 46.036 ml |
| 5 mM | 0.921 ml | 4.604 ml | 9.207 ml |
| 10 mM | 0.46 ml | 2.302 ml | 4.604 ml |
| 5 mM | 0.092 ml | 0.46 ml | 0.921 ml |
Last Update：2024-01-02 23:10:35
2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one - Reference Information
| biological activity | CID755673 is a pan-PKD1/2/3 inhibitor with cellular activity, the IC50 values were 180 nM, 280nM, and 227 nM, respectively, with approximately 200-fold higher selectivity than the other CAMKs. |
| Target | TargetValue PKD1 () 180 nM PKD3 () 227 nM PKD2 () 280 nM |
| Target | Value |
| PKD1 () | 180 nM |
| PKD3 () | 227 nM |
| PKD2 () | 280 nM |
| in vitro study | in LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocked PMA-induced HDAC5 nuclear export and blocked PKD-mediated protein transport. In prostate cancer cells, CID755673 effectively blocks cell migration and invasion and exhibits inhibitory activity on tumor cell proliferation and cell cycle distribution. In addition, CID755673 alters primary human NK cell effector function. |
| in vivo study | in a rat model of acute pancreatitis, CID755673, through inhibition of PKD/ PKD1, significantly improve the severity of necrosis and pancreatitis. |
Last Update：2024-04-09 15:16:41
![2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one](http://res.chembk.com/assets/images/structure/H957795.png)
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Product Name: 3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one Visit Supplier Webpage Request for quotationCAS: 521937-07-5
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Spot supply
Product Name: CID755673 Visit Supplier Webpage Request for quotationCAS: 521937-07-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one Visit Supplier Webpage Request for quotationCAS: 521937-07-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: CID755673 Visit Supplier Webpage Request for quotationCAS: 521937-07-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one Visit Supplier Webpage Request for quotationCAS: 521937-07-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
Trichostatin A from Streptomyces platensis
1172453-94-9
17594-47-7
2-(2-methyl-3-nitrophenyl)acetyl chloride
4-(6-BROMO-1H-INDOL-3-YLMETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
1-(pyridin-3-yl)butan-1-one
31637-96-4
2-(isopropoxyMethyl)phenylboronic acid
N'-[(Dibromoamino)acetyl]-2-methylquinoline-3-carbohydrazide
Trichostatin A from Streptomyces platensis
1172453-94-9
17594-47-7
2-(2-methyl-3-nitrophenyl)acetyl chloride
4-(6-BROMO-1H-INDOL-3-YLMETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
1-(pyridin-3-yl)butan-1-one
31637-96-4
2-(isopropoxyMethyl)phenylboronic acid
N'-[(Dibromoamino)acetyl]-2-methylquinoline-3-carbohydrazide